Bilingualism represents an interesting model of possible experience-dependent alterations in brain structure.  The current study examines whether interhemispheric adaptations in brain structure are associated with bilingualism.  Corpus callosum volume and cortical thickness asymmetry across 14 regions of interest (selected to include critical language and bilingual cognitive control areas) was measured in a sample of Spanish-English bilinguals and age- and gender-matched monolingual individuals (N = 39 per group).  Cortical thickness asymmetry of the anterior cingulate region differed across groups, with thicker right than left cortex for bilinguals and the reverse for monolinguals.  In addition, two adjacent regions of the corpus callosum (mid-anterior and central) had greater volume in bilinguals.  The findings suggest that structural indices of interhemispheric organization in a critical cognitive control region are sensitive to variations in language experience.